Urticaria is a common dermatologic disorder in both children and adults, affecting 15-20% of the world's population. When it lasts more than 6 weeks, it is called chronic urticaria whose prevalence varies between 0.1 and 3%. It is a cosmopolitan pathology whose etiology is unknown. Chronic urticaria has a significant negative impact on the quality of life of those who suffer from it.
It is a retrospective and multicenter study over a period of six months, from May 09, 2016 to October 8, 2016. It concerned patients who consulted for ambulatory chronic urticaria in the following hospitals in Kinshasa: Hôpital du Cinquantenaire de Kinshasa/Kasa-vubu, Clinique Bondeko/Limete, Centres Hospitaliers Akram/Gombe et Hôpital General de référence de Matete/Matete. 135 patients were the definitive sample of this study.
1525 patients were received for dermatoses including 220 for urticaria. 135 had chronic urticaria, i.e., 8.8% of dermatoses and 61.3% of urticaria. 66% of chronic urticaria were spontaneous and 34% physical. The female sex was in the majority by contribution to the male sex. The oldest patient was 3 years old and the oldest 88 years old. The mean age of participants was 30.5 years, the age group 31-45 years were the most affected
chronic urticaria is a frequent affliction in the middle because reaching 8.8% of dermatoses with a female predominance.
Fetal anemia; Fetomaternal hemorrhage; Kleihauer-Betke test
Urticaria is one of the most common dermatological disorders in both children and adults, as 15-20% of the population has had or will have at least one urticaria and / or angio-Edema during its lifetime. When it lasts more than 6 weeks, chronic urticaria prevalence ranges from 0.1 to 3% [1,2], women are more commonly affected than men (3.8 times) , It is a frequent pathology whose etiology is unknown , although in 45% of cases an autoimmune etiology is called into question . Chronic urticaria has a significant negative impact on quality of life and patients with chronic urticaria have poorer quality of life than those suffering from allergic respiratory diseases or psoriasis . Clinically, it manifests itself as a fleeting eruption made of erythematous plaques, papular “ortié”, pruriginous, persisting from a few minutes to a few hours, disappearing without leaving traces, and migrating, other elements appearing elsewhere.
The lesion of urticaria corresponds to an edema which may be dermal or dermo-hypodermic due to phenomena of vasodilation with increased capillary permeability following an influx of inflammatory mediators whose main is histamine and also prostaglandins, leukotrienes, cytokines, etc. These mediators have cellular, plasma, nervous and alimentary origin. The activation of mast cells is the cause of urticaria. Immunological or non-immunological mechanisms may be responsible for this activation . In the Democratic Republic of the Congo, in Kinshasa, we have not found in the literature data on the state of this cosmopolitan pathology.
Thus, the aim of this study is to determine the epidemiological and clinical profile of chronic urticaria in order to improve therapeutic and psychosocial management.
This was a retrospective, multicenter study that took place over a six-month period from May 09, 2016 to October 8, 2016. It involved patients who had been referred for ambulatory chronic urticaria in four dermatology departments of Kinshasa: Hôpital du Cinquantenaire de Kinshasa/Kasa-vubu (n=23), Clinique Bondeko/Limete (n=37), Centres Hospitaliers Akram/Gombe (n=45), Hôpital General de référence de Matete/Matete (n=30). A total of 135 patients were the final sample of this study. The variables studied were: age, sex, occupation, marital status, history of allergic and / or autoimmune diseases, diagnosis, paraclinic assessment and treatment.
We obtained the informed consent of all the participants and all the information gathered in the selected files remained confidential, the security measures concerning confidentiality were guaranteed: anonymity, limited access to data, location, the inability to identify subjects when publishing the study results.
The data was entered on Epi data. After checking, these were exported to SPSS 15.0. The results are expressed in absolute frequency and in proportions or percentage. The threshold value of statistical significance was at p˂0.05.
Out of 1525 outpatient dermatology patients in selected hospitals, only 220 were suffering from urticaria, including 135 chronic urticaria (all etiology combined), a frequency of 8.8% of dermatoses and 61.3% of urticaria.
66% of chronic urticaria were spontaneous and 34% physical (Table 1).
The female sex was the majority, 85 patients compared to 50 male (Table 2).
The patient’s age ranged from 3 to 88 years. The mean age of the participants was 30.5 years, patients between the ages of 31-45 years were the most affected.
Clinically, we have pointed out the oedematous papuleuses in 25% of the cases, lesions of scratching in 37% of the cases and the positive dermographism in 12% of the cases (Table 3).
Almost half of the patients had already had a hives crisis in the past. The majority of patients (95) reported that their quality of life was severely affected during crises. 68 patients, that is to say 50%, are said to practice self-medication.
Acne (25%) and mycoses (20%) were the most common dermatoses associated, sinusitis and asthma were the non-dermatological pathologies encountered in 32 and 15 patients, respectively.
38% of the patients were employees and 32% of the students. In the majority of cases, in 81 patients, we were unable to identify the probable cause of chronic urticaria.
The inflammatory assessment performed in 80 patients revealed an increased VS in 5% of cases, leucocytosis in 3% of the cases. FAN (Anti-Nuclear Factor) had returned positive in 1% of cases, thyroid function was disrupted in 7 patients. 3% of patients were diabetic. The majority of patients were treated with antihistamines: anti-H2 alone (68%), in combination with anti-H1 (30%), in 2% of the cases a corticosteroid was necessary to stabilize the patient.
In our series, chronic urticaria accounted for 8.8% of dermatoses, this frequency differs according to study environments. Balp et al., in a study in 5 EU countries (France, Germany, Italy, Spain and the United Kingdom) had a frequency of 0.5% and 0.2% . The spontaneous chronic urticaria were the most encountered compared to the chronic physical urticaria, this observation follows that of Zhong et al. . A strong female predominance was noted in relation to the male sex, Gaig et al., in Spain , Zuberbier et al., in Germany , Zhong in China . This could be explained by the fact that a woman would be more sensitive than the man to the different nociceptive stimuli so they consult more than men.
An average age of 30.5 years was found with age extremes of 3-88 years, in the literature variable data are found, Zhong in China  had an average age of 34.7 years, Zaraa in Tunisia  had 36 years with the extremes of age of 1-79 years, data superior to ours. More than half of the patients stated that this condition affected their quality of life, this is in line with the studies by Balp et al.,  and Zhong and Col . This is due to the fact that the resulting pruritus makes this pathology invalid and difficult to live. In the majority of cases chronic urticaria was idiopathic, similar data are reported in the literature [11-13]. Idiopathic urticaria was retained as a diagnosis of elimination when all known causes accessible to a reasonable balance sheet were discarded. This is a waiting frame since it reflects the insufficient knowledge of the factors that can trigger hives.
The paraclinic results revealed positive FAN in 1% of cases, thyroid function disrupted in 5 patients, increased VS in 2% of patients; These findings are consistent with the relationship between chronic urticaria and autoimmune diseases, as cited in the literature and some studies on this subject [11,14]. This can be justified by a high prevalence of autoantibodies and the existence of a chronic inflammatory process during these diseases.
Second-generation antihistamines were prescribed for first-line treatment in all patients, 2% of whom had oral corticosteroids due to the persistence of pruritus despite the use of antihistamines. 2nd generation antihistamines are the treatment of choice in first intention and when the cause is identified it must of course be taken into account. Our patients showed a significant improvement following regular treatment with antihistamines. We have not found in the literature elements in favor of a given molecule [15,16].
Chronic urticaria is a frequent affliction in hospitals because reaching 8.8% of dermatoses, women are more affected than men. It predominantly reaches the active adult population and the psycho-social repercussions are not negligible.
|Chronic urticaria physical||34|
|Chronic urticaria spontaneous||66|
Table 1: Types of chronic urticaria.
Table 2: Distribution by sex.
|Clinical Lesions of Urticaria||%|
|Lesions of scratching||37|
Table 3: Types of clinical lesions.