Journal of Clinical Dermatology & Therapy Category: Clinical Type: Case Report

A 19-Year Old Female with Toxic Epidermal Necrolysis and Acute Pulmonary Failure was Successfully Treated with Extracorporeal Membrane Oxygenation: A Case Report and Review of the Literature

Roeleveld YWF1, Cleffken BI1, Dokter J1, Oen IMMH1 and Van Der Vlies CH1*
1 Department of surgery and burns, Maasstad Hospital, Rotterdam, Netherlands

*Corresponding Author(s):
Van Der Vlies CH
Department Of Surgery And Burns, Maasstad Hospital, Rotterdam, Netherlands
Tel:+31 102911911,

Received Date: Apr 15, 2015
Accepted Date: Jul 06, 2015
Published Date: Jul 20, 2015


Toxic Epidermal Necrolysis (TEN) otherwise known as Lyell’s syndrome is a potentially life threatening condition, with mortality rates up to 35%. TEN is mostly caused by adverse drug reactions and can vary in severity of expression for skin lesions and mucous membranes, like the eyes, the buccal mucosa, the respiratory system, the gastro-intestinal tract and the urogenital tract.

We present the case of a 19-year old female with a rapidly progressive TEN with involvement of almost 100% of the skin. Also her eyes and the respiratory tract were severely affected leading to respiratory insufficiency. Being unable to support her with conventional mechanical ventilation, she was treated with Extracorporeal Membrane Oxygenation (ECMO).


Toxic Epidermal Necrolysis (TEN) otherwise known as Lyell’s syndrome is a potentially life threatening condition. It especially involves skin and mucous membranes. TEN is mostly caused by adverse drug reactions and can vary in severity of expression for skin lesions. When classified as most severe, mortality rate rises up to 35% [1]. We describe the use of extracorporeal membrane oxygenation in a patient with TEN resulting in severe respiratory failure.


A 19-year old female was admitted to our burn centre in 2011 with a rapidly progressive TEN. 16 days before presentation she was prescribed with Pipemidic Acid (PPA) for a urinary tract infection, until 2 days before admission she had switched to nitrofurantoin.

On admission she had normotension with tachycardia of 100bpm, tachypnea (16/minute), a maximal Glasgow Coma Scale and a temperature of 40.4?C. She had blisters on her trunk, arms and head. Besides that she had petechiae on her legs. The affected skin involved 45% of her Total Body Surface Area (TBSA) (Figure 1). She was admitted to the ICU of our burn centre. The first day she was treated with amoxycillin and clavulanic acid and support was provided with rehydration and oxygen administration. Next day antibiotic treatment was changed to meropenem and gentamycin in response to bacteriological culture results: Haemolytic Streptococci type B and Bacillus cereus. Prophylactic fluconazole and hydrocortisone were started.

Figure 1:
 Large parts of her skin were affected.

One day after hospitalisation she developed a septic shock with high fever up to 41.2?C. There was severe increase in surface area of the skin lesions (90% TBSA). As a new finding mucous membranes of the eyes and the respiratory tract were affected. Serous secretions rapidly increased as a result of lesions in mucous linings. With anticipated troublesome intubation a primary tracheostomy was performed. Upon placement of the tracheostomy device roughly 400ml of serous secretion was evacuated.

On ventilator support the patient rapidly deteriorated with high pressure control ventilator settings (FiO2100%, positive end expiratory pressure 20mm H2O, peak pressure 40mm H2O), resulting in a PaO2 of 47mm Hg. With Nitrogen ventilation initially there was some improvement (FiO2 90%) in her respiratory failure. Pleural effusion and increasing interstitial abnormalities were visible on chest X-ray (Figure 2). Pleural cavity drainage evacuated 250ml pleural effusion and with bronchial intermittent suctioning intrapulmonary effusion up to 150-300ml each 15 minutes was evacuated.

Figure 2: Chest X-ray showed pleural effusion and increasing interstitial abnormalities.

Being unable to support her with conventional mechanical ventilation, she was transferred by mobile intensive care unit to a tertiary medical referral centre for ventilation with Extracorporeal Membrane Oxygenation (ECMO). The affected skin expanded to almost 100% TBSA. Prophylactic Zovirax was added to treatment. While on ECMO treatment, ventilator settings were lowered for peak pressure and FiO2 to minimize barotraumas. To prevent adhesion and collapse of alveoli PEEP was maintained at 20mm H2O. Pulmonary conditions gradually improved, with diminishing secretions with bronchial evacuations. As a result patient was weaned of ECMO six days after transfer. She was transported back by mobile intensive care unit to our burn centre with regular ventilator settings.

During hospitalisation she developed a septic shock with Staphylococcus and Enterococcus bacteraemia as a result of skin lesion contamination. She was successfully treated with antibiotics. Her skin recovered with fast reepithelialization (Figures 3A and B). Twenty-one days after admission she was successfully weaned of the ventilator and her tracheostomy device was removed.

Figure 3: Re-epithalisation on day 18 (A) and day 32 (B) after admission.

Besides skin lesions and pulmonary problems, the patient’s eyes were involved. Both conjunctivae and cornea of both eyes were affected. Her eyes were treated with corticosteroids from the first day of admission. The tendency to form symblepharon made the ophthalmologist decide to perform amnion membrane transplantation (Figure 4).

Figure 4: Amnion membrane transplantation.

Fourty-six days after admission she was transferred to rehabilitation centre. Her skin lesions spontaneously recovered, but post inflammatory hyper pigmentation remains. Her eyesight did not completely recover. Her vision is still reduced, caused by neovascularisation, symblepharon and corneal scarring.


Toxic epidermal necrolysis, also known as Lyell’s syndrome, was first described in 1956 by Alan Lyell. TEN is a rare condition with an incidence of approximately 1 to 2 cases per million per year [1,2]. TEN especially involves the skin and mucous membranes.

The histopathological feature is probably disruption of the epidermal-dermal junction, which results in hemorrhagic erosions, erythema and epidermal detachment, presenting as blisters and areas of denuded skin. The pathogenesis is probably immune mediated, but is not fully understood. T-lymphocytes have been identified to play a role in the initiation phase [1,3].

In most cases, TEN are caused by medication (75%) [3,4]. In the weeks before admission our patient used two different antibiotics; pipemidic acid and nitrofurantoin. Probably one of these drugs was the cause of TEN.

The treatment of TEN is based on supportive care and removal of the causative agent. Because a large part of the skin could be affected, patients are very sensitive to infections and dehydration. Treatment mainly consists of rehydration, antibiotic treatment if necessary and wound dressings. This combination of care can ideally be given in a burn centre. With larger percentages of TBSA affected, sometimes admission to an intensive care unit is necessary.

In TEN patients mucous linings like the eyes, the buccal mucosa, the respiratory system, the gastro-intestinal tract and the urogenital tract can be affected [5]. In over 50% of all patients diagnosed with TEN, treated at a burn centre, the eyes are affected [6-8]. In our patient, the eyes and the respiratory tract were severely affected.

Her eyes were initially treated with eye drops and ointment: trimethoprim/polymyxin B sulfate, ofloxacine and corticosteroids. The tendency to form symblepharon made the ophthalmologist decide to perform an Amnion Membrane Transplantation (AMT). The most common treatment for ocular involvement is topical antibiotics, topical steroids and lubricants [9]. In AMT the amnion membrane is sutured to the eyelids to cover the entire ocular surface as a temporary biological bandage. AMT in patients with TEN was first reported by John et al., in 2002 [10]. Since then AMT in patients with TEN was described in some cases. Recent literature suggests that AMT suppresses inflammation, prevents ulcer formation and promotes healing, and as a consequence prevents sight-threatening sequelae [11,12].

Our patient developed also pulmonary complications with the need of ventilation with ECMO. Conventional mechanical ventilation was insufficient to support her. Bronchial suctioning was performed every 15 minutes, necessitated by desaturations, evacuating up to 300ml each time, with end expiratory pressures of 20mm H2O. She was transferred to a tertiary medical centre for ventilation with ECMO. To our knowledge, in the literature only two case reports about a TEN-patient treated with ECMO were described [13,14].

The comparison between these cases is the development of Acute Respiratory Distress Syndrome (ARDS) with occurrence of large volumes of broncho-alveolar secretions due to the mucous lesions in her respiratory system. Other causes of pulmonary complications in TEN patients could be a community-acquired pneumoniae, a nosocomial mechanical ventilation infection or a combination of these.

Because full recovery is typical in TEN patients, these patients are ideal candidates for ECMO, when severe pulmonary dysfunctions develop as demonstrated in these cases. [13,14] ARDS is the most common cause for pulmonary complications in TEN patients.

As showed in this case, TEN can be a life-threatening condition. The mortality rate of TEN is 25-35% [1]. Sepsis is the most common cause of death [3]. The prognosis for TEN can be predicted on basis of the SCORTEN score (Table 1). This is a prognostic scoring system especially for patients with TEN, using 7 determinants observed within the first 24 hours after admission [15]. Our patient had a SCORTEN score of three (heart rate ≥ 120/min and TBSA involved at day 1 > 10%, Serum bicarbonate < 20mmol/L), which corresponds to a predicted mortality of 35.3%. On the first day of hospitalisation, her prognosis was relatively good. On the second day her pulmonary conditions deteriorated and the affected TBSA expanded to almost 100%. She developed the need for ventilation support and with ongoing respiratory insufficiency the need for ECMO. Clearly her clinical status was with a poor prognosis, although her SCORTEN score was still three.

Items Presence=1, Absence=0 Score Predicted Mortality
Age ≥ 40 years 0-1 3.2 %
Malignancy 2 12.1 %
Heart rate ≥ 120/min 3 35.3 %
TBSA involved at day 1 > 10% 4 58.3 %
Serum urea > 10mmol/L >5 90.0 %
Serum glucose > 14mmol/L  
Serum bicarbonate < 20mmol/L

Table 1: SCORTEN score.


TEN with nearly 100% TBSA involvement can be treated with full recovery of the skin. In a patient with pulmonary complications (ARDS) secondary to TEN, ECMO should be considered as a rescue therapy. Furthermore, amnion membrane transplantation for ocular involvement could be an option for treatment. Our patient recovered completely with only sequelae to eyes and hyperpigmentation of the skin.


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Citation: Roeleveld YWF, Cleffken BI, Dokter J, Oen IMMH, van der Vlies CH (2015) A 19-Year Old Female with Toxic Epidermal Necrolysis and Acute Pulmonary Failure was Successfully Treated with Extracorporeal Membrane Oxygenation: A Case Report and Review of the Literature. J Clin Dermatol Ther 2:10.

Copyright: © 2015  Roeleveld YWF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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