Sclerotherapy with Polidocanol Foam prepared with room air causes some side effects which can become dangerous. In order to decrease or even avoid such adverse effects, the Foam with pure oxygen was prepared. The study was approved by the ethics committee, with the informed consent of the patients. The sclerotherapy was made with polidocanol Foam prepared with the gas-liquid proportion of Tessari's method. Two groups were formed, one was treated with polidocanol-room air foam and the other with polidocanol-oxygen foam, which used pure oxygen (O2) n instead Room air (Ra). No special exclusion criteria between groups.
Patients = 1300, adverse effects: Cough (0.15% O2, 3.7% Ra), Dizziness and migraine (0%, O2, 0.53% Ra), Visual disturbances (0%, O2, 0.13% Ra), Back pain (0%, O2, 0.73% Ra). The effectiveness of treatment was the same in both groups, but the Foam prepared with oxygen had better performance. Although Dr.Frullini has demonstrated that endothelin is the cause of the neurologic side effects, the use of physiological gases can prevent most of the undesirable’s effects of the sclerosing Foam. In conclusion, Foam sclerotherapy performed with Oxygen is a good option to reduce or even prevent adverse effects of polidocanol, easy to performance and with better stability in the Foam.