Journal of Angiology & Vascular Surgery Category: Medical Type: Original Research

Endovascular Treatment with the pCONus Device: Initial Experience in a Single UK Centre

Fozia Saeed1*, Tufail Patankar2 and Anthony JP Goddard2
1 Department of neurosurgery, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, United kingdom
2 Department of neuroradiology, Leeds General Infirmary, Leeds, United kingdom

*Corresponding Author(s):
Fozia Saeed
Department Of Neurosurgery, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, United Kingdom
Tel:+44 7701344725,

Received Date: Apr 13, 2017
Accepted Date: Jun 28, 2017
Published Date: Jul 12, 2017


Background: Wide-necked intracranial bifurcation aneurysms are complex and difficult to treat. Several novel devices have been developed for treatment using endovascular approaches. We present the results of our initial experience of using the pCONus device in our centre.

Methods: This retrospective study includes 7 patients who underwent endovascular treatment for wide-necked (≥4mm) intracranial aneurysms. 4 aneurysms were unruptured and 3 were acutely ruptured at the time of treatment. Initial and follow up radiological and clinical outcomes are presented.

Results: A total of 6 aneurysms were successfully treated with the pCONus device whilst one aneurysm resulted in barrel stent assisted coiling due to the inability to deploy pCONus. There were two complications with the development of a thrombus during the procedure-resolution was observed following further administration of anti-coagulation. At six month follow-up, 83% of the aneurysms showed complete occlusion or stable sub-total occlusion on radiological imaging and all patients had a mRS score of 0.

Conclusion: In this initial case series, pCONus stent assisted coiling for wide-necked bifurcation aneurysms is safe and provides good clinical and radiological outcomes. Long term follow-up is required to determine efficacy of this device.


Endovascular Treatment


The use of Endovascular Treatment (EVT) has gained prominence since the International Subarachnoid Aneurysm Trial (ISAT) as an effective method of treating both ruptured and unruptured intracranial aneurysms [1-3]. However wide-necked aneurysms present a challenge to short-term and long-term endovascular outcomes and consequently a range of supplementary techniques and devices have been developed in recent years. These include balloon assisted coiling, stent assisted coiling, flow diversion and flow disruption devices [4-7].

Despite these developments the treatment of intracranial Wide-Necked Bifurcation Aneurysms (WNBA) remains complex, primarily due to the technical difficulties of preserving both bifurcation branches. More recently a novel device the pCONus bifurcation aneurysm implant (Phenox, Germany) has been designed for WNBA. The pCONus device is an advancement of the waffle cone technique which involves inserting a self-expanding stent into the parent vessel whilst its distal tip is implanted into the neck of the aneurysm to hold the coils in place [8].

The aim of our study is to report our initial experience of using the novel pCONus device for EVT of intracranial aneurysms in a series of consecutive cases.


Patient characteristics: Retrospective data collection of all patients who underwent pCONus assisted coil embolisation was undertaken at the Leeds General Infirmary, Leeds, UK between the periods of December 2015 through to June 2016. Patients were considered for treatment with the pCONus device if the aneurysm was wide-necked, located at vessel bifurcations and following discussion at a multi-disciplinary meeting. There were 5 women and 2 men with a mean age of 63.3±10.1 years.

Device description: The pCONus device (Phenox GmbH, Bochum, Germany) is a laser cut stent-like structure specifically designed for WNBA (Figure 1). The distal end (‘crown’) comprises of 4 petals and a nylon net which is deployed into the aneurysm to support the coil mass and prevent it from protruding into the parent vessel. The petals are available in 6 diameters ranging from 5mm to 15mm. The shaft remains within the parent vessel and has favourable qualities that lower thrombogenicity. The diameter of the shaft is 4mm and is available in two lengths (20mm, 25mm). The device is detached through an electrolytic detachment process but may be completely recovered. Another advantage of this device includes a proximal marker and four radio-opaque markers on each of the petals, allowing for accurate positioning of the device.

Figure 1: Illustration of the pCONus bifurcation aneurysm implant. Image used from Phenox (Germany), with permission.
Endovascular procedure: Informed consent was obtained from all of the patients. Two experienced interventional neuroradiologists (AJPG, TP) performed the procedure with all patients under general anaesthesia. Femoral access was gained using a standard 6F/8F (Neuron MAX) guide catheter. A bolus of Heparin (5000 units) was administered followed by a further dose if required to increase the Activated Clotting Time (ACT) to twice that of baseline. 3D rotational angiography was performed. The most appropriate pCONus size was determined by measuring the aneurysm width, height and neck width. Initially a microcatheter (Prowler Select © Cordis neurovascular, USA) was navigated to the centre of the aneurysm. The pCONus device was then delivered through the microcatheter deploying the crown first. The petals are expanded as the microcatheter is carefully withdrawn to allow them to sit at the aneurysm neck. Continuous fluoroscopy was utilised to visualise the positioning of the device at the neck of the aneurysm. The device was successfully repositioned as necessary to optimise neck coverage. The coils are subsequently deployed through the device with a microcatheter (SL-10) and navigated through the stent into the aneurysm. The coiling catheter was withdrawn once satisfactory occlusion had been achieved and the pCONus device was then detached.

Antiplatelet/Anticoagulation regime: Before treatment, all patients received antiplatelet therapy as shown in table 1. During the procedure, patients received a bolus of 5000 units Heparin followed by a further dose if required to keep the ACT at or above twice baseline. All elective patients were given a bolus dose of 300 mg of Aspirin and Clopidogrel one week before the procedure. Post-procedure patients were continued on Aspirin 75mg indefinitely and Clopidogrel 75mg for 6 weeks.

PatientNo. Presentation AneurysmsTreated Location Parent Vessel Diameter (mm) Aneurysm Size (mm) Aneurysm neck (mm) Device Anti-plateletBT Anti-platelet AT  
1 Unruptured 1 R MCA 2-3 6 x 6.8 x 10.3 4.6 pCONus asp+clop clop 6/52 ?asp indefinitely  
2 Ruptured/Recurrence 1 L AcomA 2-3 5 x 5.4 x 5.7 6.1 pCONus asp+clop cbp 6/12 asp indefinitely  
3 Unruptured 1 R MCA 2-3 11.8 x 12.3 x 12.6 12.7 pCONus asp+clop cbp 6/52 asp indefinitely  
4 Unruptured 2 L MCA + Lpericallosal 2-3 7.3 x 8 x 9.22 8.6 barrel asp+clop cbp 6/52 asp indefinitely  
5 Ruptured 2 L MCA + L PcomA 2-3 4.4 x 5.7 x 6.4 4.4 pCONus dcagrelor ISOmg+asp Ig ticagralor 180mg 6/52 asp indefinitely  
6 Ruptured 1 Basilar tip 3 7.5 x 9.4 x 9.6 6.3 pCONus prasugrel 60mg+isp Ig prasugrel 10mg 6/12 asp indefinitely  
7 Ruptured 1 L AcomA 2-3 6.3 x 9.3 x 8.1 6.0 pCONus asp lg cbp 6/52 asp indefinitely  
Table 1: Aneurysm characteristics.

R - Right; L - Left; MCA - Middle Cerebral Artery; AcomA - Anterior communication Artery; PcomA - Posterior communicating Artery; BT - Before Treatment; AT - After Treatment; asp - aspirin; clop – Clopidogrel

Different regimes were used for patients with acutely ruptured aneurysms (Table 1). One patient developed a clot in the parent vessel and received 10mg Abciximab during the procedure which successfully dissolved the clot. Post-procedure patients were commenced on Aspirin 75mg once daily indefinitely and either Clopidogrel 75mg, Prasugrel 10mg or Ticegrelor 180mg daily ranging from either 6 weeks to 6 months (Table 1).

Data collection: Ethical approval was sought but not required for anonymised retrospective data collection. Data collected included patient’s age and gender, clinical presentation, aneurysm characteristics (location, size, dome to neck ratio) and technical and clinical complications. Post procedure angiographic results were classified based on the Raymond classification scale: complete occlusion, residual neck or residual aneurysm [9]. The patients were clinically examined pre and post-procedure for any neurological symptoms/signs. The clinical course of each patient was recorded and 6 month outcomes were graded using the modified Rankin Scale (mRS).

Patient follow-up: Patients were reviewed in follow-up clinic at 6 weeks and underwent 6 month follow-up imaging with Magnetic Resonance angiography (MRI 3T, Siemens) with and without gadolinium contrast agent.


Aneurysm characteristics

EVT with the pCONus device was attempted in 7 patients with a total of 7 aneurysms. Of these, 3 were acutely ruptured aneurysms in patients presenting with subarachnoid haemorrhage and 4 were unruptured aneurysms (one recurrence). The location of ruptured aneurysms included Middle Cerebral Artery (MCA); Anterior Communicating Artery (AComA); and basilar termination. The unruptured aneurysms were located on the MCA and the recurrence was on the AComA. In this patient cohort, there were two additional (posterior communicating and pericallosal artery) aneurysms treated with coils in two of the patients.

As a result of the device characteristics only aneurysms with a neck of ≥4mm were treated with the pCONus device. The aneurysms ranged in size with the average dome size as 8mm (range 4.4-12.6mm) and average neck size as 7mm (range 4.4-12.7mm). Aneurysm characteristics are summarized in table 1.


There were intra-procedural complications observed in two patients. Both developed a thrombus of the parent vessel which was immediately treated with Abciximab and Aspirin during the procedure. There were no clinical or radiological sequelae.

Post-procedure, one patient returned with a small retroperitoneal haematoma adjacent to the puncture site. This was managed conservatively and resolved spontaneously. Another patient developed transient expressive dysphasia which spontaneously resolved within a few hours. There were no deaths.

In one case, there was procedural difficulty placing the pCONus device across the MCA aneurysm bifurcation branches and the device was therefore retrieved and replaced with a barrel stent (Medtronic Inc.).

Immediate outcome

Six patients with WNBA were treated with a single pCONus device. The Raymond classification scale was used to determine immediate outcomes. Post-angiography results showed 1 patient (16.7%) had complete occlusion of the aneurysm whilst 5 patients had remnants of the aneurysm (66.6%) and neck (16.7%) remaining. In one of these patients with an acutely ruptured AComA aneurysm, the remnant was deliberately left to preserve an anterior cerebral artery origin. At discharge, one patient reported temporary left arm numbness, which resolved spontaneously. No patient experienced permanent neurological morbidity.


All patients were reviewed in the neurovascular clinic at 6 weeks. MRA was performed on average 6 months post-stent assisted embolisation. Radiological follow-up showed a small aneurysm remnant in one patient a small neck remnant in another patient (both stable compared with end-procedure angiography), one neck recurrence and 3 completely occluded aneurysms, as shown in table 2. The patient treated with a barrel stent had significant recurrence and is currently awaiting re-treatment. During the available follow-up period, there has been no evidence of aneurysm rupture or delayed thromboembolic events. All patients had a mRS score of 0.

Patient No. Intra-opComplications ProcedureComplications Postangiography Result 6 Month Follow-up(MRA) mRS
1 nil nil small remnant complete occlusion 0
2 nil nil small remnant complete occlusion 0
3 nil nil small remnant neck remnant 0
4 nil unable to deploy pCONus -barrel stent used complete neck recurrence 0
5 Thrombus nil complete complete occlusion 0
6 nil nil small remnant neck recurrence 0
7 Thrombus nil small remnant small remnant 0
Table 2: Clinical and radiological outcomes post-treatment.

Illustrative cases

Illustrative cases are shown in figures 2A-D and 3A-D.
Figure 2: Case of a patient with an acutely ruptured basilar tip aneurysm treated with pCONus (A before treatment, B pCONus device in-situ before coil deployment, C Coils deployed and D after treatment). At 6 months follow-up, MRA showed a small neck recurrence which is undergoing surveillance.
Figure 3: Case of a patient with an unruptured right MCA aneurysm treated with pCONus (A before treatment, B pCONus device in-situ before coil deployment, C Coils deployed and D after treatment). At 6 months follow-up, MRA showed complete occlusion of the aneurysm.


Despite recent advances in endovascular techniques, wide-necked bifurcation aneurysms remain technically challenging to manage due to the combined difficulty of coil positioning away from the parent artery and achieving a high enough packing density to prevent recurrence. An ideal device to assist in coil embolisation of WNBA would have characteristics that allow complete occlusion by preventing coil herniation into the parent vessels and has long term durability with low morbidity and mortality rates. However, there is currently no single state-of-the-art EVT for WNBA.

In order to overcome some of the difficulties in treating WNBA, various techniques have been developed including balloon remodelling and stent assisted techniques. Both CLARITY and ANTENA studies compared conventional coil embolisation with balloon remodelling techniques in ruptured and unruptured aneurysms respectively and found no significant increase in morbidity or mortality [9,10]. However, aside from adding complexity to the procedure, limitations of this technique also include prolonged procedure duration and fluoroscopic time [10].

Stent assisted techniques to treat WNBA include X, Y and T stenting, linear/horizontal stenting and the waffle cone technique [5,8,11,12]. The waffle cone technique involves placing the proximal end of the stent in the parent vessel and the distal end into the aneurysm sac but it is associated with higher rates of recanalisation [13,14]. X, Y, T, and linear stenting involve a complex delivery technique as they all require the use of more than one stent [11,15,16]. More recent advances include the use of a Woven EndoBridge (WEB) device which is a braided nitinol mesh that functions as an intrasaccular flow disruptor [17-20]. One of our patients with an AComA aneurysm treated with pCONus had a recurrence following utilisation of the WEB device previously.

Another recently CE-approved device which can be used to treat wide-necked bifurcation aneurysms is the PulseRider (Pulsar Vascular, San Jose, California, USA). There are limited reports of experience with this device [21,22]. Very recently, Gory et al., 2016 published results of PulseRider stent assisted coiling in 15 patients with unruptured bifurcation aneurysms. This international series found low complication rates but were unable to provide data on efficacy of the device [21].

The pCONus device is also a novel stent which has been specifically designed to assist coiling of wide-necked intracranial bifurcation aneurysms. There are several studies that have assessed the effectiveness of the pCONus device in unruptured aneurysms but only one currently published study on its use in ruptured aneurysms [23-26]. Aguilar-Perez et al., 2016, has shown encouraging results in 21 patients with ruptured aneurysms that were treated with the pCONus device [23]. The authors reported the device as safe and effective for use in ruptured aneurysms but based on short term follow-up results alone.

In our study, EVT with pCONus was successfully performed in six of the seven patients. In one patient the device had to be retrieved due to the inability to place it safely across the middle cerebral artery. The complexity of this case was a result of asymmetrical branches making it difficult to place the pCONus device at the aneurysmal neck in a satisfactory position. This could possibly represent a limitation of this device. Immediate angiogram results showed complete occlusion in one patient and 5 small aneurysm and neck remnants. In line with other studies, the overall performance of the device has so far produced satisfactory clinical results [23-27]. There were no significant clinical complications associated with the use of the device and all patients were discharged with no permanent neurological deficits.

However a significant limitation of stent-assisted coiling with the pCONus device is the need for anticoagulation and anti-platelet therapy peri- and post-procedure. More often, anti-platelets are continued lifelong as the risk of thrombo-embolic complications is reported as ranging between 7-15% [28-30]. This indeed can be problematic, particularly in acute cases of ruptured intracranial aneurysms where risk of bleeding-related complications are higher following SAH sequelae such as hydrocephalus needing surgical intervention or vasospasm resulting in cerebral ischaemia predisposing to haemorrhagic transformation [31-35]. This controversial issue remains a challenge for neurointerventionalists. Bodily et al., 2011, reported an overall procedure-related risk of up to 13% in ruptured cases versus 6-7% in unruptured cases [30,31,36]. Though it is unknown if this difference in risk is truly in relation to the inherent differences or due to confounding factors such as technical differences.

More commonly encountered longer term problems in EVT include recannalisation and recurrence rates of 20% and 10% respectively [37]. Follow-up result of our patients with the pCONus device at 6 months demonstrated 83% with stable complete or sub-total occlusions. The patient who underwent barrel-assisted embolisation was found to have a recurrence of the MCA aneurysm and is awaiting further treatment. In addition, the lack of consistency in pre-procedure antiplatelet regime may have contributed to the intra-procedural complication of thrombus encountered in two of the cases.

The limitations of our study are typical for a single-centre retrospective analysis. We also experienced difficulty with imaging as the stem of the pCONus device appears to cause an artefact on MRA and therefore catheter angiogram may be required for follow-up imaging. Further limitations of this study include the small patient cohort included and unavailable long term follow-up results. However as this is a novel EVT, preliminary results are, in our opinion, vital to engage in the safety and efficacy of this device. We also propose the need for large multi-centre studies to accurately determine the risks of stent-assisted EVT in ruptured aneurysms before final conclusions are made.


Our preliminary results have shown that EVT with the pCONus device is an effective method for treating wide-necked bifurcation ruptured and unruptured aneurysms. Overall clinical and radiological outcomes are successful and short-term occlusion stability compares well with other series for comparable aneurysms. Larger and long term follow up studies will be needed to assess the benefits of the pCONus device in treatment of intracranial aneurysms.


AJPG, TP: Conception and design of the work
FS: Acquisition and analysis of the data, interpretation of data, manuscript preparation
FS, AJPG, TP: Drafting the work and critical revision
FS, AJPG, TP: Manuscript preparation and critical revision of the manuscript


Sought but not required due to nature of anonymised data collection.


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Citation: Saeed F, Patankar T, Goddard AJP (2017) Endovascular Treatment with the pCONus Device: Initial Experience in a Single UK Centre. J Angiol Vasc Surg 2: 008.

Copyright: © 2017  Fozia Saeed, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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