Objective: To evaluate early and mid-term outcomes of patients with Pulmonary Atresia, Ventricular Septal Defect (PA-VSD), Major Aorto-Pulmonary Collateral Arteries (MAPCAs) with severely ‘diminutive’ native pulmonary arteries treated with a surgical or hybrid first approach. An initial palliative strategy is necessary to relieve cyanosis, to enhance pulmonary arteries growth and to bridge selected patients with a poor anatomy to the surgical complete repair.
Methods: We retrospectively reviewed our database to detect all the neonates diagnosed with PA-VSD, MAPCAs and severe hypoplasia of native Pulmonary Arteries (PA), who underwent surgical or hybrid first approaches between January 2005 and December 2015. First surgical palliation consisted of the placement of an aorto-pulmonary shunt (modified Blalock-Taussing Shunt). Hybrid procedure was the perventricular stenting of the Right Ventricle Outflow Tract (RVOT) through medial sternotomy.
Results: We analysed 11 patient’s data: 5 patients underwent the surgical and 6 the hybrid approach. There were no differences between the cohorts in demographic and clinical data. Surgical patients were younger at first procedure while native pulmonary arteries diameter and Nakata index were found to be lower in the hybrid group. All the procedures were successful except for one of the hybrid group; this patient underwent a surgical shunt during the same procedure. No immediate and early deaths or major complications occurred. Eight patients achieved the unifocalization with or without VSD closure at a mean age of 8.27+/-5 months. Three patients of the initial 11 died during the follow-up, one of them due to a non cardiac cause. Surviving patients were followed up for a period of 12 to 137 months.
Conclusion: Hybrid RVOT perventricular stenting provide a feasible and effective alternative compared to the standard surgical technique, for the initial management of patients with unfavourable PA anatomy. Mid and longer term outcomes of this cardiopathy and survival rates depend mainly on native pulmonary arteries size and growth.
Congenital heart disease; Diminutive native pulmonary arteries; Hybrid palliation; Multifocal pulmonary vascularization; Neonates; Perventricular stenting; Right ventricle outflow tract
Pulmonary Atresia (PA), Ventricular Septal Defect (VSD) and severely Hypoplastic Pulmonary Arteries is a rare and complex cardiac disease in which multifocal pulmonary vascularization exists supplied by Major Aortopulmonary Collateral Arteries (MAPCAs). The number, size, origin and course of MAPCAs are variable, such as the native pulmonary arteries size which can range from almost normal to completely absent [1,2]. In natural history of this disease there is a progressive stenosis and occlusion of MAPCAs [2,3] so, this condition requires early intervention to relieve cyanosis and to enhance the growth of the native pulmonary arteries. In cases of adequate weight and pulmonary artery size, one stage surgical unifocalization can be achieved with good results, as reported by Reddy, Abella et al., cit [2,4,5]. However, in some cases the pulmonary arteries are diminutive and therefore a staged approach is preferable.
Surgical techniques require cardiopulmonary bypass which is poorly tolerated by small infants. First surgical palliation consists of the placement of an aorto-pulmonary shunt in these patients [6,7], whilst in other cases a transannular patch is created. Stenting of the arterial duct [8] and Radiofrequency (RF) perforation of the atretic segment [9] are non-surgical alternatives, but such procedures may be particularly challenging.
Hybrid procedures on small infants have been reported [10-12] by performing a transventricular puncture and a perforation of the atretic outflow tract, followed by transluminal balloon dilation or stenting of the Right Ventricle Outflow Tract (RVOT) which showed good early results.
We analyzed early and long term outcomes of patients with PA-VSD, diminutive pulmonary arteries and multifocal pulmonary vascularization, referred to our center and treated with surgical or hybrid first approach to restore pulmonary flow.
We retrospectively reviewed the cardiovascular database of the Gaslini Institute to detect all neonates diagnosed with PA-VSD and MAPCAs, between January 2005 and December 2015. The following data was retrieved from clinical and procedural records: gender, age, weight, body mass index, Nakata index, associated extra-cardiac malformations or syndromes, age at first intervention, types of first interventions, major peri-procedural and post-procedural complications, additional interventions, follow-up duration, age at and cause of death, and outcome for survivors.
At our institution, the hybrid approach to PA-VSD was introduced in November 2007; previously, RF perforation or surgical approach was the treatment of choice. At present we select patients according to anatomical and clinical features to assess the best individual approach.
All the procedures were performed according to the guidelines of the local Ethics Committee and informed consent was obtained from the parents. Hemodynamic data was collected and multiple angiographies were performed: aortic root injection was made to detect collaterals of head and neck vessels and to document the coronary arteries anatomy. Descending aortogram by occlusion technique with a 5F Berman catheter via an antegrade venous approach was performed to demonstrate the number and location of MAPCAs (Figure 1). Then selective hand-injections in MAPCAs to delineate the multifocal perfusion of the lungs was undertaken to determine which type of pulmonary artery connection was present. Collaterals found connected to native pulmonary arteries could be coil occluded, stenotic collaterals isolated from native pulmonary arteries could be dilated.
Figure 1: Antero-posterior view of descending aortogram by occlusion technique with a 5F Berman catheter.
We also performed pulmonary vein wedge injections to identify central pulmonary arteries if initial aortogram and selective injection of the MAPCAs did not demonstrate a pulmonary artery confluence (‘seagull’). The Nakata index was calculated using the formula:
RPA area (mm2) + LPA area (mm2)/BMI (m2) [13]. Values of >200 were considered optimal for repair.
Patients were successively scheduled for surgical or hybrid procedures.
Hybrid procedures were carried out in a hybrid surgical suite using high resolution biplane fluoroscopy. Access was provided through medial sternotomy, under general anesthesia. The surgeon performed the exposition of the heart and the isolation of the pulmonary arteries, and created a pursestring with 6.0 prolene at the right ventricle wall; following this, he picked the right ventricle infundibulum with an Abocatt needle 20 to 24 Gauge (Arrow) directed across the atretic pulmonary valve. Under fluoroscopy, the interventional cardiologists, advanced a short tipped stiff coronary guide wire (0.014) into the main pulmonary artery and placed it in one of the pulmonary branches or through the patent arterial duct into the descending aorta (Figure 2). A 4 or 5 French introducer sheath, was positioned 2 cm into the RVOT (a prolene marker was secured to the base of the sheath to help to arrive in the correct position). After a small contrast injection and sizing (Figure 3), one or multiple predilatations of the RVOT were performed with a coronary balloon. Finally coronary stents of different measures were implanted into the RVOT. The median diameter of coronary stents deployed was 3.5 mm, with a range of 3-4.5 mm, and the median length was 13 mm, with a range of 8-16 mm. In one case 2 stents, 3x12mm and 3.5x13 mm respectively, were positioned in overlap. Stents were deployed from just above the pulmonary valve until within the right ventricle outflow tract, restoring flow to the native pulmonary arteries (Figure 4).
Figure 2: Antero-posterior view, after medial sternotomy, of the coronary guide wire placed trough the main pulmonary artery into the right pulmonary branch.
Figure 3: Antero-posterior view of the right ventricle outflow tract after balloon predilatation.
Figure 4: Antero-posterior view of the right ventricle outflow tract after stent deployment.
Data is described as absolute and relative frequencies for categorical variables, while means, Standard Deviation (SD), medians, and range are used for continuous variables.
Non parametric analysis (Mann-Whitney tests) for continuous variables and the Chi square or Fisher's exact test for categorical variables were used to measure differences between groups. A p-value less than 0.05 were considered statistically significant; all p-values were based on two-tailed tests. Statistical analysis was performed using SPSS for Windows (SPSS Inc., Chicago, Illinois USA).
Eleven patients attended our Institution with the diagnosis of PA-VSD and MAPCAs during the study period. We divided patients into 2 groups according to the first therapeutic approach received. The surgical cohort consisted of 5 patients: 4 of them underwent a modified Blalock-Taussing shunt (mBT) and one of them received an outflow patch. The hybrid cohort consisted of 6 patients who underwent perventricular transcatheter balloon pulmonary valvuloplasty and/or stenting of the RVOT; with one of them undergoing concomitant placement of an mBT shunt. In our cohort we identified 2 genetic anomalies in the hybrid group (1 deletion of 22q11 and one anomaly of chromosome 8) and one duodenal atresia in the surgical group.
Table 1 shows the baseline demographic and clinical characteristics, the preoperative risk factors, the age at the procedures and the follow up duration for the patients. There were no differences between the cohorts in gender, weight, height, BMI and transcutaneous Oxygen saturation levels, while native pulmonary arteries diameter and Nakata index were found to be lower in hybrid group. Patients scheduled for surgical treatment were younger at first approach than patients underwent hybrid procedures.
Characteristics |
ALL |
Surgical |
Hybrid |
P value |
|
N=11 |
N=5 |
N=6 |
|||
Weigh at first procedure, gr, Mean ± SD |
3224±749 |
2800±474 |
3267±602 |
0.33 |
|
Median (range) |
3100 (2300, 5000) |
2600 (2300, 3400) |
3150 (2500, 4300) |
||
Heigh at first procedure, cm |
51.5±3.8 |
49.4±2.79 |
52.3±3.2 |
0.13 |
|
50 (47, 59) |
48 (47, 54) |
52 (49, 58) |
|||
BMI, m2 |
0.12±0.1 |
0.11±0.1 |
0.12±0.1 |
0.66 |
|
0.12 (0.10, 0,14) |
0.11 (0.10, 0,13) |
0.12 (0.10, 0,13) |
|||
Native PA diameter, mm |
2.3±1.58 |
3.4±1.34* |
1.67±0.52 |
0.05 |
|
2 (0, 5) |
4 (2, 5) |
2 (1, 2) |
|||
Nakata Index, mm2 /m2 |
113.3±111 |
178.4±126** |
41.5±22.8 |
0.03 |
|
57 (12, 356) |
193 (52, 356) |
52 (12, 63) |
|||
Age at 1st procedure, days |
33.7±30.8 |
16.6±22.8* |
34.5±19.7 |
0.05 |
|
25 (2, 120) |
7 (2, 57) |
26 (12, 60) |
|||
Age at 2nd procedure, months |
8.27±5 |
5.15±2.36 |
12.25±6.55 |
0.2 |
|
7 (2, 20) |
6 (2, 7) |
12.5 (4, 20) |
|||
Age at 3rd procedure, years |
4.33±2.8 |
5.67±3.2 |
3 |
1 |
|
4 (1, 8) |
7 (2, 8) |
3 |
|||
O2 Sat pre-procedure,% |
76.7±6.7 |
78±9.1 |
74.2±2 |
0.79 |
|
75 (70, 90) |
75 (70, 90) |
75 (70, 75) |
|
||
O2 Sat post first procedure,% |
84±6.3 |
85±7.1 |
81.67±2.6 |
0.66 |
|
|
80 (80, 100) |
80 (80, 95) |
80 (80, 85) |
|
|
Final O2 Sat ,% |
90.5±9.2 |
94.75±9.8 |
87±9.2 |
0.49 |
|
|
90 (80, 100) |
99.5 (80, 95) |
84 (80, 100) |
|
|
Follow- up, months |
72.9±40 |
91.5±49 |
62.5±42.4 |
0.49 |
|
|
73 (12, 137) |
96.5 (36, 137) |
67 (12, 103) |
|
Table 1: Demographic and Clinical Characteristics.
Mean ± SD , Median (range)
*Surgical vs Hybrid p=0.05; ** Surgical vs Hybrid p=0.03
Legend: PA: Pulmonary Arteries; BMI: Body Mass Index; O2 Sat: Oxigen Saturation levels.
The study did not experience any incidence of death or major complications during or immediately after the first procedures in any of our patients and oxygen saturation levels improved in patients across both the groups. All the procedures were successfully performed with one exception. One patient within the hybrid group had a failed attempt of dilation of the RVOT without stenting and underwent immediate surgical mBT-shunt during the same session. One late mBT shunt occlusion occurred in a patient within the surgical cohort 2 years from the date of the procedure; percutaneous reperfusion was unsuccessfully attempted, and other surgical options were not considered feasible. The patient died 2 years later.
Eight of our 11 patients underwent a second procedure of unifocalization at the mean age of 8.27+/-5 months.
In 2 patients within the surgical group unifocalization was performed and the Ventricular Septal Defect (VSD) was left open, while in 2 cases it was possible to close the VSD.
Four patients of the hybrid group underwent unifocalization. In one patient the unifocalization was performed and VSD was successfully closed while in 3 cases the VSD was left open. One of them had a late conduit thrombosis and died 2 years later.
Another patient of the hybrid cohort died due to a non-cardiac cause and the last one is still waiting for a second procedure. Our patients were followed up for a period of 12 to 137 months. Three patients from the initial 11 died (27.2%): 1 within the surgical group (20%) and 2 within the hybrid group (33.3%), (p=0.11). Four patients achieved complete repair with VSD closure (3 surgical and 1 hybrid). Further procedures in these patients consisted of a deferred VSD closure, conduit substitution, biological pulmonary valve implantation and MAPCAs percutaneous occlusion. Three patients after unifocalization still have their VSDs open and 2 of them underwent percutaneous multiple dilatations of the pulmonary arteries. Two patients in follow up had no more surgical options available and 1 is still awaiting further procedures. The data is summarized in the flow-chart.
Flow-chart: mBT occl. = Modified Blalok Taussing Shunt occlusion; Unifoc = Unifocalization; VSD = Ventricular Septal Defect; PTA AP: Percutaneous Angioplasty of Pulmonary Arteries; FUP = Follow-Up; PV Impl.= Pulmonary Valve Implantation; MAPCAs = Major Aortopulmonay Arteries Collaterals
The management of patients with PA-VSD and MAPCAs with Hypoplastic Native Pulmonary Arteries is still challenging. Early age intervention is often required and often complicated by low weight. When native pulmonary arteries are severely hypoplastic, multistage approaches are preferable to promote the growth of these arteries [14]. When pulmonary arteries are completely absent the only option is to perform palliative procedures of MAPCAs dilatation where possible but the prognosis for such patients is unfavorable [15].
Percutaneous approaches such as radiofrequency perforation are possible, but are burdened with a high risk of perforation especially if a long muscular atretic segment is present. Ductal stenting is another option but sometimes unfavorable ductal anatomy, such as long and tortuous ducts, makes this procedure complex with the risk of uncompleted stenting [8]. In small low weight infants percutaneous procedures are also complicated by access problems.
Surgical techniques consist of a modified Blalock-Taussing shunt (m-BT shunt) [6] and a transannular patch, but they require cardiopulmonary by-pass which is poorly tolerated in very small infants [16,17]. Furthermore, an m-BT shunt in very small arteries can involve complications such as early or late occlusion, distortion of pulmonary arteries shape with asymmetrical growth, stenosis of the pulmonary branches and pulmonary overcirculation.
Hybrid technology combines the achievements of both surgical and percutaneous techniques to bring benefits to patients with different congenital cardiac disease with a minimally invasive approach [18]. We attempted hybrid procedures in selected patients with extreme hypoplasia of native pulmonary arteries. These procedures allowed to avoid cardiopulmonary by-pass, eliminated percutaneous access problems, allowed antegrade pulsatile flow into the pulmonary arteries and minimized the shape distortion of pulmonary arteries. The most challenging maneuver in the procedure is the perventricular RVOT puncture due to the risk of going the wrong way into the muscular infundibulum. Other technical complications include the sheath instability and the loss of conventional radiological landmarks. To deploy a stent in the RVOT has the potential to compress a coronary artery [19,20], but the small diameters of the stents employed (stents are chosen 1.5 to 2 mm larger than pulmonary trunk) and the muscular tissue that surrounds them, minimizes this risk in small patients.
Hybrid procedures have been demonstrated to be a safe and feasible alternative to conventional approaches, a great cooperation between the surgeon and the interventional cardiologist is required. This can offer patients better opportunities to improve survival and future quality of life.
In our follow up, we also observed patients who underwent all types of approaches, inadequate growth of native pulmonary arteries, which made it impossible to proceed to VSD closure after unifocalization. Poor pulmonary vascularization and cyanosis lead to limitations in exercise and stress tolerance and required multiple palliative procedures of MAPCAs and pulmonary artery dilatation or stenting throughout life. In some patients no more surgical options were feasible and progressive cyanosis led to death.
The retrospective approach and the small sample size were the major limitations of our study: this severe form of cardiopathy is rare; moreover, we considered only patients with very diminutive or absent pulmonary arteries and therefore application of findings outside of the specified study criteria needs to be approached with due caution.
This is the first study, to our knowledge, to compare the hybrid approach for restoring flow in native diminutive pulmonary arteries in PA-VSD and MAPCAs to the standard surgical approach. We reported the largest number of patients who underwent this hybrid procedure.
Hybrid approach is a safe and feasible alternative to mBT shunt, with a high rate of technical immediate success and low rate of procedural complications. It reduces the exposure to cardiopulmonary by-pass, which may have long-term effects, particularly in neonates; promotes a more balanced growth of the pulmonary branches and also prevents the shape distortion and future stenosis of very small native pulmonary arteries. Our experience demonstrated encouraging results to expand the use of this procedure to bridge high risk patients with diminutive pulmonary arteries to final surgical repair. However, the prognosis of this cardiopathy is poor. Mid and longer term outcomes and survival rates depend mostly on the native pulmonary arteries diameter and growth. Multiple surgical or percutaneous palliations are required to improve oxygen saturation levels, exercise tolerance and general quality of life of these patients.
No disclosure to declare.
Citation: Bondanza S, Calevo MG, Santoro F, Marasini M (2020) Hybrid and Surgical First Approach for Pulmonary Valve Atresia and Ventricular Septal Defect in Small Infants: Single Center Early Results Comparison and Mid-Term Outcomes Analysis. J Angiol Vasc Surg 5: 034.
Copyright: © 2020 Sara Bondanza, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.