Journal of Clinical Studies & Medical Case Reports Category: Medical Type: Case Report

Maternal Death Due to Sagittal Sinus Thrombosis-Autopsy Diagnosis: A Case Report

Burcu Kasap1*, Emre Canverenler2, Kenan Karbeyaz3, Melike Erbas3, Yasemin Balci4 and Eren Akbaba5
1 Department of obstetrics and gynecology, School of Medicine, Mugla Sitki Kocman University, Mugla, Turkey
2 Department of obstetrics and gynecology, Sinop State Hospital, Sinop, Turkey
3 Justice ministry, Institute of Forensic Medicine, Eski?ehir, Turkey
4 Justice ministry, Institute of Forensic Medicine, School of Medicine, Eskisehir, Turkey
5 Department of obstetrics and gynecology, School of Medicine, Mugla Sitki Kocman University, Eskisehir, Turkey

*Corresponding Author(s):
Burcu Kasap
Department Of Obstetrics And Gynecology, School Of Medicine, Mugla Sitki Kocman University, Mugla, Turkey
Tel:+90 2522114800/5156,,

Received Date: Jan 06, 2015
Accepted Date: Mar 18, 2015
Published Date: Apr 01, 2015


We report a case of 30 years old maternal death due to sagittal sinus thrombosis after delivery via cesarean section. The woman had two previous cesarean deliveries and admitted to emergency department with severe headache and loss of sensation at one side of her leg on the postpartum eighth day. Sagittal sinus thrombosis and intracerebral hematoma were diagnosed by both clinical and radiological examinations. The patient was unable to survive despite the intensive treatment period. Herein, we report the evaluation of autopsy findings by forensic medicine. In conclusion, the evaluation of maternal mortality cases also with autopsy findings might yield accompanying effective factors and might cause a decrease in maternal mortality rates.


Autopsy; Maternal death; Sagittal sinus thrombosis


Cerebral Venous Thrombosis (CVT) occurs due to occlusion of cerebral venous sinus or cortical veins. The most common form is the Superior Sagittal Sinus (SSS) thrombosis. The coexisting etiologic factors like infection, head trauma, surgical interventions and tumors increase the frequency of thrombosis formation [1]. CVT may be seen in all ages of men and women but incidence rate of CVT increases in fertile women due to oral contraceptive use, pregnancy and postpartum period.

Diagnosis can be confirmed by cerebral angiography, computed tomography and magnetic resonance images. Prognosis is variable and sometimes it may regress spontaneously.

CVT mostly occur in puerperal period of the pregnancy. Cortical venous thrombosis which may lead to cerebral infarction or bleeding is also a complication of pregnancy and mostly occur within three weeks after delivery. The most commonly affected region is the SSS. The incidence rate of SSS thrombosis during pregnancy differ according to the developmental level of the country. The incidence of SSS thrombosis is 1 per 250 pregnant women in India meanwhile its incidence is very low in European countries [2]. This condition can be caused to the lack of diagnostic and treatment facilities. Herein, we report a case of 30 years old maternal death due to sagittal sinus thrombosis after delivery via cesarean section and aim to evaluate autopsy findings.


A 30 years old pregnant woman delivered at term by emergent Cesarean Section (CS) due to indication of previous cesarean operations in a tertiary referral training and research hospital. CS was performed under spinal anesthesia. The patient was discharged from the hospital at the third postpartum day in a stable condition without any complications due to operation. She was totally asymptomatic by means of neurological sytem at the time of discharge. But she was admitted to emergency department with severe headache, loss of sensation at one side of her leg and coughing on the postpartum eighthday. She was hospitalized at Neurology Department with the prediagnosis of SSS thrombosis. Although the cranial angiography report revealed normal findings, a hematoma of 37 x 33 mm size at left parietal lobe and asymmetrical lateral ventricules were detected via cranial tomography. At this stage intervention was not planned by neurosurgery specialists. Patient was given anticoagulant and anti-edematherapy. Afterwards, the second cranial tomography examination reported a secondary hyperdense focus in vertex and a 2 mm shift to right side. In the follow-up condition of the patient was further aggravated and comatous state occured. At the sixteenth postpartum day “brain death” diagnosis was accepted by a committee including specialists of neurosurgery, anesthesiology and cardiology at twenty first postpartum day.


External examination

Incision site due to CS and evidence of medical interventions.

Internal examination

There was neither epidural nor subdural hematoma detected inside the cranial cavity. The diameters of the sagittal sinus, sinus rectus and right transverse sinus were enlarged upto 1.5 cm dimensions and coagulum formations were detected in those enlargements (Figure 1). Intracerebral hematoma of 4 x 4 x 2 cm size in left parietal region and minimal bleeding areas in brain stem were detected. A 2 x 2 cm size of intracerebral bleeding, which was being fed by left medial cerebral artery, was seen by autopsy examination (Figure 2). All the arteries of brain were dilated but there was notan evidence of aneurysma. In thoracal examination, bilateral lungs were found to be larger than normal. In serial cuttings intense edema and intense mucous in bronchi were present.

Figure 1: Thrombus Formation in Sagittal Sinus.

Figure 2: Intracerebral hematoma in the regions being fed by median cerebral artery and dilatation in all cerebral veins.

Histopathological examination

Intraparenchymal bleeding points in brain stem, thrombus in sagittal sinus, acute pneumonia, diffuse alveolar destruction and intraalveolar edema were detected histopathologically.

In conclusion, the death of the patient was thought to be caused by pathological bleeding in brain and this etiology was aggravated by severe acute pneumonia.


Thrombosis of cerebral veins or sinuses is a cerebrovascular disease which may be misdiagnosed or diagnosed too late. It may happen in all ages but mostly in young and middle aged women [3]. Clinical presentation may vary and can be so dramatical. It is suddenly presented with headaches due to intracranial hypertension, focal neurological problems, convulsions and lethargy [3,4]. The reported case was also presented with headache and lethargy but the situation of the patient got worse during hospitalization. Many etiological factors are reported in the literature but in 20-25% of the cases exact etiology could not be identified [3]. Mortality rate is 5-30% [4,5]. Many of the cases might completely recover. But residual neurological sequela in 20% of the patients and epileptic convulsions in 5% of the patients may remain [4-6].

Severe dehydration, last trimester of the pregnancy, genetical disorders of the coagulation mechanism like protein C or S deficiency, infections like otitis and mastoiditis or septisemia, malignancy, head trauma and hematological disorders are the major risk factors for CVT [6]. Diagnosis might be performed by advanced neuroradiological examinations [7].

In patients with known genetic predispositions, anticoagulant therapy such as low molecular weight heparin could be done for prevention especially in postpartum period . When SSS thrombosis formed therapy can vary such as corticosteroids, barbiturates, cerebrospinal fluid drainage, craniectomy for decompression, thrombectomy, heparin, local urokinase and tissue plasminogen activators. Although anticoagulant therapy can be successful in some cases, it is still controversial. Some authors have concluded that some patients can heal in three weeks to six months without any medical or surgical treatment.

Pregnancy is a prothrombotic state due to changes in hemostatic sytem. These physiological changes are mandatory for the safety of fetoplacental circulation but it might lead to formation of thrombi. These changes in hemostatis become evident after the second trimester of pregnancy. The levels of fibrinogen, factor VII, VIII, IX, X, XII, high molecular weight kininogen and prekallikrein increase during pregnanacy [8,9]. These changes in hemostatic parameters do not completely return to normal levels in the early postpartum period. So the patients with coexisting etiologic factors for thrombosis may gain extra risk at the postpartum period. In this case report, the clinical symptoms were marked approximately one week after birth and with radiological examination the diagnosis of the SSS thrombosis was suspected. An intracerebral hematoma with a size of 3 cm was detected but notany surgical intervention was thought. Postmortem findings were supportive for the suspected clinical diagnosis.

In this paper, we reported a maternal death by sagittal sinus thrombosis due to predisposition to clotting after birth. The minimal intracerebral hematoma and severe pneumonia were also thought to be effective in this thrombosis predispositon.


Citation: Canverenler E, Kasap B, Erba? M, Karbeyaz K, Balc? Y, et al. (2015) Maternal Death Due to Sagittal Sinus Thrombosis-Autopsy Diagnosis: A Case Report. J Clin Stud Med Case Rep 2: 012.

Copyright: © 2015  Burcu Kasap, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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