Journal of Clinical Studies & Medical Case Reports Category: Medical Type: Review Article

Mesenchymal Hamartoma: A Review of Literature

Saccomanni Bernardino1*
1 Department: Orthopaedic And Trauma Surgery, Bari Viale Regina Margherita, Altamura (Bari), Italy

*Corresponding Author(s):
Saccomanni Bernardino
Department: Orthopaedic And Trauma Surgery, Bari Viale Regina Margherita, Altamura (Bari), Italy
Tel:+39 3208007854,

Received Date: Aug 24, 2021
Accepted Date: Sep 06, 2021
Published Date: Sep 13, 2021


Mesenchymal Hamartoma is a rare, benign osseous tumor that typically involves the rib cage and presents during the first year of life. There is a case of this tumor originating in the cervical spine, described in literature. I document a brief literature review. In this review, there are not figures and outcomes.


Mesenchymal hamartoma; Spine


Mesenchimal hamartomas are rare, benign osseous tumors that typically involve the rib cage and present during the first year of life [1-9]. Aggressive growth is not part of the natural history, and surgical excision is generally curative. Fewer than fifty cases have been reported in literature to date. To my knowledge, there have been a case report of this tumor originating in the spine. The lesion appears expansile on radiographs and often causes deformity of the chest wall and ribs. It may be lobulated, is primiraly cartilaginous, and may contain bone trabeculae. 

Although most of these lesions are benign, malignant transformation has been reported [5]. Epidemiology, Pathologic findings, biopsy, treatment. Mesenchimal hamartoma is a rare tumor that has not previously been described as originating from the spine and more specifically, from the cervical spine in an adult. 

Mesenchymal hamartoma most commonly presents as a chest-wall deformity, respiratory compromise, or pneumothorax in an infant or as an incidental finding on a chest radiograph. There have been reports of this tumor being detected in utero [6]. The features of this tumor are usually those of an aggressive, expansile lesion that most commonly originates from a rib. 

Fine-needle aspiration has assisted in the diagnosis of these tumors [6,9]. Surgical resection is the optimal treatment and has been associated with a low rate of recurrence [3,5]. One case of malignant transformation has been reported [5]. There is a case of mesenchymal hamartoma originating from the spinal column. In the case of this patient, the clinical and imaging findings suggested compression as opposed to invasion of the caudal roots of the brachial plexus. Standard principles of oncological care suggested that a biopsy should be performed prior to excision, but it was the consensus opinion, at an oncology conference that an excisional biopsy would minimize the risks of recurrence and would not compromise the patient’ s care. 

Given the age of the patient, the location of tumour, and expansile nature of the lesion, the initial differential diagnosis focused on benign primary tumors of the spine, specifically, aneurysmal bone cyst and giant-cell tumor. The surgical pathological diagnosis of mesenchymal hamartoma was unspected. 

In conclusion, this unusual tumor should be added to the differential diagnosis of posterior element primary spinal tumors. These tumors may ancroach upon adjacent neural and vascular structures, causing symptoms in addition to local pain. Wide surgical resection appears to have resulted in successful treatment in the case of the cervical spine.


Citation: Bernardino S (2021) Mesenchymal Hamartoma: A Review of Literature. J Clin Stud Med Case Rep 8: 0122.

Copyright: © 2021  Saccomanni Bernardino, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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