Journal of Genetics & Genomic Sciences Category: Genetics Type: Review Article
Recurrent Pregnancy Loss: Proposal for a Novel Diagnostic Protocol with New Molecular Genetics Insight
*Corresponding Author:Carmelo Piscopo
Medical And Laboratory Genetics Unit, A Cardarelli Hospital, Naples, Italy
Received Date: May 19, 2020 Accepted Date: May 21, 2020 Published Date: May 28, 2020
Recurrent Pregnancy Loss (RPL) is defined as three consecutive Pregnancy Loss (PL) prior to 20 weeks of gestation, about 1-2% of women will be affected [1,2]. Recently, the American Society of Reproductive Medicine (ASRM) has redefined RPL as two or more pregnancy losses . Using this definition, the incidence of RPL is up to 5% of women [1-3]. Different risk factors are associated with RPL, including advanced maternal age, and number of previous miscarriages . Although RPL remains unexplained in about 50% of the cases, gynecological, endocrinological, immuno-hematological and genetical factors have been described.
Citation:Piscopo C, Saccone G, Santangelo C, Iolascon A, Monica MD (2020) Recurrent Pregnancy Loss: Proposal for a Novel Diagnostic Protocol with New Molecular Genetics Insight. J Genet Genomic Sci 4: 018.
Copyright: © 2020 Carmelo Piscopo, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.