Recurrent Pregnancy Loss: Proposal for a Novel Diagnostic Protocol with New Molecular Genetics Insight
*Corresponding Author(s):
Carmelo PiscopoMedical And Laboratory Genetics Unit, A Cardarelli Hospital, Naples, Italy
Tel:39 0817472291,
Email:carmelo.piscopo@aocardarelli.it
INTRODUCTION
Recurrent Pregnancy Loss (RPL) is defined as three consecutive Pregnancy Loss (PL) prior to 20 weeks of gestation, about 1-2% of women will be affected [1,2]. Recently, the American Society of Reproductive Medicine (ASRM) has redefined RPL as two or more pregnancy losses [3]. Using this definition, the incidence of RPL is up to 5% of women [1-3]. Different risk factors are associated with RPL, including advanced maternal age, and number of previous miscarriages [1]. Although RPL remains unexplained in about 50% of the cases, gynecological, endocrinological, immuno-hematological and genetical factors have been described.
Citation: Piscopo C, Saccone G, Santangelo C, Iolascon A, Monica MD (2020) Recurrent Pregnancy Loss: Proposal for a Novel Diagnostic Protocol with New Molecular Genetics Insight. J Genet Genomic Sci 4: 018.
Copyright: © 2020 Carmelo Piscopo, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
