Journal of Orthopedic Research & Physiotherapy Category: Medical Type: Research Article

Current Evidence for Biomechanical Principles in the Management of Knee Osteoarthritis, Review of Literature

Mohammed Elmajee1, Ahmed Aljawadi2*, Anand Pillai3, Noman Niazi4, Noman Jahangir4 and Omar Alsawaf4
1 Trauma and orthopaedics, Orthopaedics Training Program, Birmingham, United kingdom
2 Trauma and orthopaedics, Wythenshawe Hospital, Manchester, M23 2RW, United kingdom
3 Consultant trauma and orthopaedics, Wythenshawe Hospital, Manchester, M23 2RW, United kingdom
4 Trauma and orthopaedics, Wythenshawe Hospital, Manchester, M23 9LT, United kingdom

*Corresponding Author(s):
Ahmed Aljawadi
Trauma And Orthopaedics, Wythenshawe Hospital, Manchester, M23 2RW, United Kingdom

Received Date: Sep 02, 2019
Accepted Date: Oct 07, 2019
Published Date: Oct 14, 2019


Knee OA is a common condition and it commonly affects medial compartment of the knee. Biomechanical forces applied to the knee during ambulation play an important role in the development of knee OA. The objective of this study is to evaluate the currently available evidence assessing the biomechanical principles that may be applied in the management of knee OA.

Methods and Result
a comprehensive search of the relevant literature published between 2005-2019 has been conducted. There was an evidence to suggest a link between the biomechanical axis around the knee joint and the development of knee OA. Varus and valgus knee malalignments affect the External Knee Adduction Moment (EKAM) resulting in medial or lateral knee component OA, respectively. Biomechanical measures used for management of knee OA will have a tiny effect on EKAM, however, it can compensate for the forces applied around the knee joint, off-loading the compressed compartment of the knee. Yet, this effect is only symptomatic, and the disease process will continue as long as the biomechanical axis along the knee joint is not changed.

Knee joint offloading measures (e.g. Braces, foot insoles), can be effective to alleviate the symptoms associated with knee OA. However, this is not related to the disease process and it is unlikely to stop the progression of knee joint OA.


Arthroplasty; Biomechanics; Brace; Conservative; Knee osteoarthritis; Osteotomy


Osteoarthritis (OA) is the most common joint disease in adults around the world, it is a progressive disease resulting in chronic joint pain and significant disability [1,2]. The knee is one of the most frequently affected joints by OA [3]. According to Metcalfe, et al. 2013, more than 40% of people over 60 years of age have symptomatic knee OA, and more than 50% of these have bilateral knee OA [4]. In knee OA, the Medial Compartment (MC) is the most commonly distressed as during the stance phase of gait, more than 70% of the load applied to the knee joint passes through the MC, as the centre of mass passes through the medial to the centre of the knee joint [5]. In spite of being a common condition, the aetiology of knee OA is unclear. It is assumed to be a multifactorial disease, the result of a complex interplay of metabolic, genetic, biomechanical, and biochemical factors. OA is characterized by an increased local concentration of inflammatory cytokines, cartilage matrix degeneration and deposition of inappropriate sub-chondral bone [2,6]. Generally, the onset and evolution of knee OA has been linked to the mechanics of ambulation, consequently, there is a lot of literature suggesting that manipulating the biomechanical conditions around the knee joint during ambulation may have a significant influence on severity, progression and outcomes of the knee OA [7].

The objective of this review is to evaluate the relevant evidence-based biomechanical principles that may be applied for the management of knee OA (mainly the MC, as it is the most commonly affected). Different management options will be outlined with respect to biomechanical principles, and then the role of knee braces for the management of knee OA will be critically discussed from a biomechanical point of view.


A comprehensive search of the most relevant literature was conducted using the following keywords: knee osteoarthritis, biomechanics, conservative, brace, osteotomy and arthroplasty. The search was performed using the following search engines: Midline, Cochrane, Springer, ScienceDirect, google scholar and Web of Science. The search included papers published between 2005 and 2019. Only papers that discussed the biomechanical principles behind the management of primary uni-compartmental knee OA were included.


Knee joint biomechanics and knee OA patho-mechanics

The knee joint alignment is one of the most commonly investigated factors when considering knee joint OA. Varus or valgus knee malalignment had been reported to influence the distribution of forces across the knee joint articular surface [8]. Varus malalignment of the knee is not uncommon in patients with medial compartment knee OA [9] and it increases the External Knee Adduction Moment (EKAM), leading to more compressive forces over the medial compartment of the knee [9,10]. It has been reported that medial knee compartment usually bears 60-80% of the load in people with neutral knee alignment, however a mild increase in knee joint varus alignment of around 4-5° can results in up to 20% increase in the compressive load over medial compartment [11]. Birmingham, et al. and Monil, et al., report that knee varus malalignment can create a vicious cycle, where increase knee medial compartment compressive load can result in accelerated medial compartment OA and subsequent worsening of the knee varus malalignment [9,12].

External Knee Adduction Moment (EKAM) (Figure 1) can be defined as the perpendicular distance between the Ground Reaction Force (GRF) and the centre of the knee joint, it is regarded as the relative load on the knee MC compared to the LC, which acts as a force pulling the knee in to the varus position [13,14].
Figure 1: External Knee Adduction Moment EKAM (σ). The load depends on the magnitude of the ground reaction force vector and the perpendicular moment arm from its line of action to the knee joint centre [5].

Surgical management of knee OA

The surgical option depends on many factors, such as the patient’s age, symptoms, disability and radiographic severity of the disease. There are many surgical techniques used for the management of knee OA, for instance, arthroscopic debridement, arthroplasty and osteotomy. According to the American Academy of Orthopaedic Surgery recommendations, arthroscopic debridement should only be used for patients with mechanical symptoms, such as sudden onset joint locking or instability [6]. Knee Joint arthroplasty can be considered for patients with knee OA, either Uni-compartment Knee Arthroplasty (UKA) or Total Knee Arthroplasty (TKA) [15]. Corrective osteotomies are validated option for the management of knee joint OA when varus or valgus malalignment of the knee joint are considered as the causative factors [16]. The aim is to shift the mechanical axis of the knee from the arthritis compartment to the healthy one of the knee [16]. Voleti, et al., conducted a retrospective study to evaluate outcomes of varus distal femur osteotomy for the management of lateral knee OA associated with valgus knee malalignment. All of the 13 patients included in his study were able to commence sport activities at 11 months postoperatively, with a significant improvement in their functional outcomes [17]. However, small sample size is the main limitation of this study. On the other hand, based on the results of the systemic review conducted by Amendola and Bonasia 2010, good long-term results have been reported after High Tibial Osteotomy (HTO) for patients with MC knee OA [18].

Van Outeren, et al., discussed the results of 2 Randomised Controlled Trials (RCT) assessing the outcomes of HTO compared to conservative management of knee joint medial compartment OA. HTO provided better pain control, while, functional outcomes of HTO compared to unloader brace didn’t show a statistically significant difference [19].

Conservative management of knee OA

According to Zhang, et al., 2008, the optimal conservative management of patients with knee OA should include both pharmacological and non-pharmacological modalities [20]. The most commonly recommended pharmacological treatments are acetaminophen (paracetamol), followed by Non-steroidal Anti-inflammatory Drugs (NSAID) as a second line, and intra-articular corticosteroids [21]. Non-pharmacological management includes patients’ education, weight reduction, exercise and biomechanical intervention [22]. Exercises may reduce the symptoms of knee joint OA. As has been reported by Reeves and Bowling 2011, the effects of exercise on osteoarthritic knee biomechanics is through the production of Internal Abduction Moment (IAM) (produced by the hip abductor muscles and the lateral hamstring muscles), this IAM counteracts the EKAM [23]. Additionally, Thorstensson, et al., stated that the EKAM can be reduced after 8 weeks of exercise in middle age patients who presented early in the disease process [24]. Furthermore, the role of biomechanical interventions, in the management of knee OA is through modifying the EKAM around the knee joint [23]. For instance, lateral wedge insoles (valgus insoles) can be useful to relieve pain, improve function and to slow-down disease progression through modifying the EKAM around the knee joint with MC knee OA [25].

The role of braces in the management of knee OA

OA is an epidemic with no known, effective cure. A knee with OA will be further damaged if it is not protected physically [26]. Bracing (as shown in Figure 2) could be a useful, non-invasive measure to protect the uni-compartment knee joint OA. The aim of the brace is to reduce contact stress in the affected part of the joint, it could be useful for correcting mal-alignment and decreasing impairment associated with knee OA [13]. The efficacy of valgus knee braces and foot orthoses in the management of MC knee OA were assessed through the systemic review conducted by Raja and Dewan [27]. The results suggested that knee pain (as measured by the Visual Analogue Scale, VAS), analgesic consumption and knee stiffness were decreased significantly by using offloading knee braces and foot orthoses. In addition, knee braces and foot orthoses can improve balance and physical function scores (such as McMaster-Toronto Arthritis score and Knee injury and osteoarthritis outcome score for pain and functional status). As well as, it has been reported that the prolonged use of knee braces (6-12 months) may improve muscles proprioception and several biomechanical factors (such as moments around the knee joint). However, long-term effect of foot orthoses was not discussed clearly in the study. In fact, this review assessed a significant number of studies (25) with a significant overall sample size (more than 1100 patients with knee OA), and this can enhance the result accuracy significantly. Nevertheless, there were many limitations of this review. First, a wide range of age groups were included, for instance, some of the studies included patients in their thirties, whereas other studies only included patients in their seventies. Consequently, result accuracy may be affected, as OA is an age-related disease, and different age groups may have different disease activity rates and different responses to treatment. However, a wide range of age groups would be more representative of the normal population. Second, the studies assessed different types of braces and foot orthoses, which could cause the results to contain bias, because patients’ responses to braces or to foot orthoses may be directly affected by their design, and finally, only 6 Randomised Controlled Trials (RCT) were included, while the remaining studies were either a retrospective or a prospective cohort, with no control group or randomisation, and this may affect the results accuracy significantly.

Figure 2: knee brace [28].

In addition, the biomechanical effects of valgus knee braces in MC knee OA were evaluated by Schmalz, et al., through performing gait analysis for 16 patients with MC knee OA after 4 weeks of wearing braces [29]. The results showed that the effect of moments created by the brace on the knee joint were as follows: the brace valgus moment (Mbr) was increased slightly during the early and late parts of the stance phase of the gait cycle, while it decreased in the mid stance phase (when knee flection occurs) as shown in figure 3. Additionally, the mean and maximum value of moment generated by the brace during the stance phase was equivalent to only 9 and 10 percent of the External Knee genu-varus (Adduction) Moment (EKAM), respectively (as illustrated in Table 1). This means that the knee brace did not affect the knee EKAM significantly, which leads to conclude that the actual effect of valgus knee braces is to compensate part of the external load, which is normally compensated by muscles and ligaments in an osteoarthritic knee without a brace, hence, decreasing the medial compartment load. This means that the real effect of braces regarding symptom relief could be due to its effect on relieving muscle tension and decreasing MC load. However, the small sample size limits the study’s reliability, as well as the fact that the participants’ gait was only assessed after 4 weeks of wearing the braces, and there was no baseline data of gait analysis to compare with; so, it is difficult to decide whether this result reflects the real effects of braces in patients with knee OA or it is inaccurate, as the patients’ symptoms had improved during the 4 weeks of wearing braces, due to decreased muscle spasms and improved overall joint biomechanics.
Figure 3: Mean valgus moment of brace (Mbr) for the instance phase (first 50 percent) of the gait cycle. Continued black = mean, interrupted black = mean ± 1 standard deviation, t (% GC) = time (% gait cycle) [29].



Mbr (%KAM)














Mean (10%-50% GC)







Table 1: Brace moment and percent of EKAM moment [29].
GC = Gait Cycle; Max = Maximum; KAM = External knee genu varus (adduction) moment.
In fact, the results provided by Schmalz, et al. 201 [29] were supported by many other studies, such as the studies conducted by Kutzner, et al. 2011, Moyer, et al. 2015, and Pagani, et al. 2013 [30-32]. According to Kutzner, et al. 2011, the efficacy of two types of valgus knee braces on MC load in MC knee OA in three participants was assessed [30]. The results showed that the MC compression load could be reduced up to 25% with the application of knee braces. However, the small number of participants could affect the study’s external validity significantly. Furthermore, according to a systemic review and meta-analysis performed by Moyer, et al., 2014, it has been shown that there was evidence to suggest that knee braces can decrease the MC compressive force in knee joint OA [31]. It can change the medio-lateral distribution of force across the knee and increase the MC joint space, and amoderate to large, statistically significant improvement in EKAM during walking was recorded (P < 0.001), while, no change in alignment was reported. The main reported side effects of braces were slipping, patients discomfort and skin irritation. Importantly, a significant number of studies were included (30 studies) with a total number of patients equal to (478), and this can enhance this review external validity. Still, some of the limitations of this review are, firstly, 26 out of 30 included studies were either laboratory measurements on a single day or a retrospective cohort. So, there was no randomisation process or control group, which may decrease its internal validity. Secondly, a very wide-ranging age group of patients (21-85-years-old), although being more representative of the population, could cause significant bias, especially when assessing knee OA, as it is an age-related process and patients´ functional requirements could have varied markedly.

Additionally, Pagani, et al., through recording of Electromyography (EMG) activity for 12 patients with MC knee OA in three conditions: without a brace, with a neutral brace and with a valgus brace, reported that both the neutral and valgus knee braces can decrease muscle contraction and activation compared to the condition without braces [32]. So, it could be effective in decreasing MC load, which may reduce symptoms and decelerate disease progression. However, the small number of participants and the absence of previous baseline or long-term follow-up are limitations of the study. As a summary of the main findings of the studies above, it could be concluded that there is some evidence to suggest that knee braces can help to alleviate the symptoms of MC knee OA by decreasing the MC compressive load and muscle activation, however, the effects of braces on knee alignment and EKAM was limited.

The role of braces on long-term disease progression was reviewed by Steadman, et al., 2016 [33]. It was shown that even though there is clinical evidence to suggest that knee braces can improve symptoms of knee OA, biomechanical evidence may suggest that braces may not act effectively to hinder disease progression, although braces may be effective in decreasing MC compressive load significantly in patients with MC knee OA and it may affect EKAM; but, importantly, other parameters were not changed significantly. However, regardless of the fact that EKAM is strongly associated with knee OA progression, this moment does not directly cause knee OA alone. For instance, mal-alignment is a crucial factor in the progression of knee OA, and there was no evidence reporting a significant reduction in mal-alignment with knee braces.


In conclusion, knee OA is a common condition, with many conservative measures and surgical techniques used for its management. However, considering the effectiveness of knee braces in the management of MC knee OA from a biomechanical point of view, there is some evidence to suggest that knee braces can relieve pain and stiffness associated with MC knee OA. The mechanism that leads to symptom relief is thought to be acting by opposing some of the load and compression applied on the MC in patients with MC knee OA. This load is thought to be tolerated normally by muscles and tendons around the knee joint in case of no braces being applied; so, this extra load applied upon muscles may be important in the pain accompanied with knee OA. However, evidence showed that although knee braces could relieve symptoms and MC load in knee OA, it may not be effective in the reduction of disease progression, as the braces cannot change the whole biomechanical moment generated around the knee joint in OA, which means some moment will continue its effect on the knee joint after the braces have been applied. As a result, it may be difficult to assume that knee braces could be really effective on a long-term scale. However, the effects of knee braces may be useful to delay surgery in patients with knee OA. In fact, this particular point may need to be investigated more in the future.


  1. Michael JW, Schlüter-Brust KU, Eysel P (2010) The epidemiology, etiology, diagnosis, and treatment of osteoarthritis of the knee. Dtsch Arztebl Int 107: 152-162.
  2. Gill R, Al?Adra D, Shi X, Sharma A, Birch D, et al. (2011) The benefits of bariatric surgery in obese patients with hip and knee osteoarthritis: A systematic review. obes Rev 12: 1083-1089.
  3. Englund M (2010) The role of biomechanics in the initiation and progression of OA of the knee. Best Pract Res Clin Rheumatol 24: 39-46.
  4. Metcalfe A, Stewart C, Postans N, Dodds A, Holt CA, et al. (2013) The effect of osteoarthritis of the knee on the biomechanics of other joints in the lower limbs. Bone Joint J 95: 348-353.
  5. Baert IA, Nijs J, Meeus M, Lluch E, Struyf F (2014) The effect of lateral wedge insoles in patients with medial compartment knee osteoarthritis: Balancing biomechanics with pain neuroscience. Clin Rheumatol 33: 1529-1538.
  6. Bennell KL, Hunter DJ, Hinman RS (2012) Management of osteoarthritis of the knee. Bmj 345: 4934.
  7. Andriacchi TP, Mündermann A (2006) The role of ambulatory mechanics in the initiation and progression of knee osteoarthritis. Curr opin Rheumatol 18: 514-518.
  8. Tanamas S, Hanna FS, Cicuttini FM, Wluka AE, Berry P (2009) Does knee malalignment increase the risk of development and progression of knee osteoarthritis? A systematic review. Arthritis Rheum 61: 459-467.
  9. Birmingham T, Moyer R, Leitch K, Chesworth B, Bryant D, et al. (2017) Changes in biomechanical risk factors for knee osteoarthritis and their association with 5-year clinically important improvement after limb realignment surgery. Osteoarthritis cartilage 25: 1999-2006.
  10. Petersen W, Ellermann A, Henning J, Nehrer S, Rembitzki IV, et al. (2019) Non-operative treatment of unicompartmental osteoarthritis of the knee: a prospective randomized trial with two different braces-ankle-foot orthosis versus knee unloader brace. Archives of orthopaedic and trauma surgery. 139: 155-166.
  11. Tetsworth K, Paley D (1994) Malalignment and degenerative arthropathy. Orthop Clin North Am 25: 367-377.
  12. Monil K, Milad M, Lynsey D, Margarita K, Alison M (2018) Comparison of gait biomechanics in patients with and without knee osteoarthritis during different phases of gait. Journal of orthopaedics, trauma and rehabilitation 25: 11-15.
  13. Segal NA (2012) Bracing and orthoses: a review of efficacy and mechanical effects for tibiofemoral osteoarthritis. PM R 4: 89-96.
  14. Ramsey DK, Russell ME (2009) Unloader braces for medial compartment knee osteoarthritis: implications on mediating progression. Sports Health 1: 416-426.
  15. Griffin T, Rowden N, Morgan D, Atkinson R, Woodruff P, et al. (2007) Unicompartmental knee arthroplasty for the treatment of unicompartmental osteoarthritis: A systematic study. ANZ J Surg 77: 214-221.
  16. Kolb A, Isak V, Hobusch GM, Chiari C, Windhager R (2018) Distal femoral varus osteotomy: results of the lateral open-wedge technique without bone grafting. Int orthop 1-8.
  17. Voleti PB, Wu IT, Degen RM, Tetreault DM, Krych AJ, et al. (2019) Successful return to sport following distal femoral varus osteotomy. Cartilage 10: 19-25.
  18. Amendola A, Bonasia DE (2010) Results of high tibial osteotomy: Review of the literature. Int Orthop 34: 155-160.
  19. Van Outeren M, Waarsing J, Brouwer R, Verhaar J, Reijman M, et al. (2017) Is a high tibial osteotomy (HTO) superior to non-surgical treatment in patients with varus malaligned medial knee osteoarthritis (OA)? A propensity matched study using 2 randomized controlled trial (RCT) datasets. Osteoarthritis cartilage 25: 1988-1993.
  20. Zhang W, Moskowitz R, Nuki G, et al. (2008) OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis cartilage 16: 137-162.
  21. Nelson AE, Allen KD, Golightly YM, Goode AP, Jordan JM (2014) A systematic review of recommendations and guidelines for the management of osteoarthritis: The chronic osteoarthritis management initiative of the US bone and joint initiative. Semin Arthritis Rheum 43: 701-712.
  22. McAlindon TE, Bannuru RR, Sullivan M, Arden NK, Berenbaum F, et al. (2014) OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis cartilage 22: 363-388.
  23. Reeves ND, Bowling FL (2011) Conservative biomechanical strategies for knee osteoarthritis. Nat Rev Rheumatol 7: 113-122.
  24. Thorstensson C, Henriksson M, von Porat A, Sjödahl C, Roos E (2007) The effect of eight weeks of exercise on knee adduction moment in early knee osteoarthritis-a pilot study. Osteoarthritis Cartilage 15: 1163-1170.
  25. Pagani CHF, Böhle C, Potthast W, Brüggemann G-P (2010) Short-term effects of a dedicated knee orthosis on knee adduction moment, pain, and function in patients with osteoarthritis. Arch phys Med Rehabil 91: 1936-1941.
  26. Gross KD, Hillstrom H (2009) Knee osteoarthritis: primary care using non-invasive devices and biomechanical principles. Med Clin North Am 93: 179-200.
  27. Raja K, Dewan N (2011) Efficacy of knee braces and foot orthoses in conservative management of knee osteoarthritis: a systematic review. Am J Phys Med Rehabil 90: 247-262.
  28. Gaasbeek RD, Groen BE, Hampsink B, Van Heerwaarden RJ, Duysens J (2007) Valgus bracing in patients with medial compartment osteoarthritis of the knee: A gait analysis study of a new brace. Gait posture 26: 3-10.
  29. Schmalz T, Knopf E, Drewitz H, Blumentritt S (2010) Analysis of biomechanical effectiveness of valgus-inducing knee brace for osteoarthritis of knee. J Rehabil Res Dev 47: 419-429.
  30. Kutzner I, Küther S, Heinlein B, Dymke J, Bender A, et al. (2011) The effect of valgus braces on medial compartment load of the knee joint–in vivo load measurements in three subjects. J Biomech 44: 1354-1360.
  31. Moyer R, Birmingham T, Bryant D, Giffin J, Marriott K, et al. (2015) Biomechanical effects of valgus knee bracing: a systematic review and meta-analysis. Osteoarthritis Cartilage 23: 178-188.
  32. Pagani CHF, Willwacher S, Kleis B, Brüggemann G-P (2013) Influence of a valgus knee brace on muscle activation and co-contraction in patients with medial knee osteoarthritis. J Electromyogr Kinesiol 23: 490-500.
  33. Steadman JR, Briggs KK, Pomeroy SM, Wijdicks CA (2016) Current state of unloading braces for knee osteoarthritis. Knee Surg Sports Traumatol Arthrosc 24: 42-50.

Citation: Aljawadi A, Elmajee M, Niazi N, Jahangir N, Alsawaf O, et al. (2019) Current Evidence for Biomechanical Principles in the Management of Knee Osteoarthritis, Review of Literature. J Orthop Res Physiother 5: 045.

Copyright: © 2019  Mohammed Elmajee, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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