Neurodegeneration refers to the progressive loss of structure or function of neurons, including neuronal death, and is the hallmark of a range of central nervous system (CNS) disorders such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), Huntington’s disease, and frontotemporal dementia. These conditions often share overlapping molecular mechanisms—such as abnormal protein aggregation (e.g., amyloid-beta, tau, alpha-synuclein), mitochondrial dysfunction, oxidative stress, impaired autophagy, and chronic neuroinflammation—that contribute to synaptic failure and irreversible neuronal damage.

Neurodegenerative diseases can affect specific brain regions, leading to distinct clinical phenotypes involving memory loss, motor dysfunction, language impairments, and behavioral changes. Both genetic and environmental factors influence susceptibility and disease progression. Recent advances in systems biology, neuroimaging, biomarker development, and single-cell transcriptomics are providing unprecedented insight into the complex networks involved in neurodegeneration.

The Journal of Alzheimer’s & Neurodegenerative Diseases promotes multidisciplinary research aimed at elucidating the pathogenesis of neurodegenerative disorders, improving early diagnosis through imaging and molecular markers, and accelerating therapeutic development. We welcome submissions that explore novel targets, neuroprotective strategies, disease-modifying treatments, and translational models that can bridge basic science and clinical application to address the growing global burden of neurodegenerative diseases.