Stem cell markers are essential for identifying, isolating, and characterizing distinct stem cell populations. These biomarkers—often surface proteins (e.g., CD34, CD90, CD105) or transcription factors (e.g., Oct4, Nanog, Sox2)—play critical roles in defining stem cell status, developmental potential, and lineage commitment. Accurate marker-based selection enhances experimental reproducibility and therapeutic safety by ensuring purity and consistency during expansion and differentiation.

Recent innovations, including multiplex flow cytometry and single-cell transcriptomics, enable high-resolution marker profiling, revealing subpopulations within heterogeneous stem cell pools. Spatial proteomics and live-cell imaging further allow dynamic tracking of marker expression during differentiation and tissue integration. The Journal of Stem Cells Research, Development and Therapy encourages submissions that advance the discovery of novel markers, validate marker panels for specific lineages, or optimize marker-based isolation techniques to improve stem cell-based applications, ranging from regenerative medicine to disease modeling.